Dr. Ashwini Chauhan

Faculty Name:

Dr. Ashwini Chauhan

Designation:

Associate Professor

Area:

Biotechnology

Qualification:

Ph. D. (Microbiology) [University of Kalyani, West Bengal;
Work Place: University of Texas Health Centre at Tyler, TYLER, TX, USA]

M. Sc. Microbiology [Gurukul Kangri Vishwavidyalaya, Haridwar]

B. Sc. Biology [Gurukul Kangri Vishwavidyalaya, Haridwar]

Qualified National Eligibility Test (NET-JRF), Council of Scientific and Industrial Research- University Grants Commisions, India

Teaching Field: 

Microbiology, Molecular Biology, Microbial Technology, Immunology and Biotechnology

Experiences:

• 2016 – Present : Associate Professor, Department of Biotechnology, NIIT University, Neemarana, Rajasthan (India)

• 2014 -2016: Chargé de Recherche (Research Scientist) Sanofipasteur (R & NCS), Lyon, FRANCE. Detached from Institute Pasteur, Paris/Bioaster Lyon, France
Project: Immune responses to bacterial biofilm infections- exploration of anti- S. aureus biofilm vaccine strategies

• 2012-2014: Assistant de Recherche in Pr. J.M Ghigo laboratory Institute Pasteur, Paris, France
Project: In vivo studies of bacterial biofilms - Development of clinically relevant animal models to study biofilms and evaluate antibiofilm strategies

• 2008-2012: Postdoc. Researcher in Pr. J.M Ghigo laboratory Institute Pasteur, Paris, France
Project: In vivo studies of bacterial biofilms - Development of clinically relevant animal models to study biofilms and evaluate antibiofilm strategies

• 2007-2008: Postdoc. Researcher In Dr. T. Rangasamy laboratoryU. of Rochester Medical Centre, New York, USA
Project: Investigating the role of oxidative stress and Nrf2 in regulation of innate immune response and pathogenesis of major obstructive lung diseases such as COPD and asthma using animal models.

• 2003-2007: Visiting Scientist/ Ph.D. candidate in Pr. M. Rajagopalan laboratory at Biomedical Research Center, University of Texas Health Centre at Tyler, Tyler, TX, USA
Project: Cell division of Mycobacterium tuberculosis using molecular and biochemical approaches

• 2002-2003: Junior Research Fellow-Institute of Genomics and Integrative Biology, CSIR, India
Project: Conducting study on production of bio-plastics from biological waste products.

• 2001-2002: CSIR-Junior Research Fellow-Gurukula Kangri Vishwavidyalaya, Haridwar, India
Project: Study of Rhizobium and Pseudomonas as potential bio-fertilizers for non-leguminous crops.

• 1998-1999: Research chemist at R&D Ranbaxy research Laboratory, New Delhi, India
Projects: Assay development for therapeutics, development of SOPs, GLPs for Q/C

Research Areas:

Microbiology, Biotechnology

Research Focus:

Bacterial biofilms (tissue as well as device associated), Phase variation and persistence in bacteria and its role in virulence, Anti-biofilm and anti-persister strategies, Anti-biofilm vaccines, Host-pathogen interactions

Consulting Area:

Antibiotic resistance, Bacterial persistence, vaccine strategies, in vivo biofilm animal models, Biotechnology

Other Interests:

Reading, Travelling, Cooking and Working towards social causes

Email-ID:

Ashwini.Chauhan@niituniversity.in

Information of Research Publications

Research Publication Details (From 2011 to 2016):

2016

  • Ashwini CHAUHAN, J.M. GHIGO and C. Beloin (2016), “Study of in vivo catheter biofilm infections using pediatric central venous catheter implanted in rat”, Nature protocols, 11(3): 525-541 Impact Factor 9.673 Cover page

2015
Book Chapter

  • Kalia VC, Lal S, Rashmi, Chauhan Ashwini, Bhattacharyya G (2015), “In silico reconstitution of novel routes for microbial plastic Microbial Factories”, Biofuels, Waste Treatment: volume 2 Springers Ltd., pp 299-315 Online ISBN 978-81-322-2595-9

2014

  • Chalabaev, S. Chauhan Ashwini, Novikov, A., Iyer, P. Beloin, C. Carroff, M. and J.M. Ghigo (2014), “Biofilms formed by Gram-negative bacterial pathogens undergo lipid A palmitoylation increasing their in vivo survival”, mBio, 5(4), Impact Factor 6.88>
  • D. Lebeaux*, Ashwini Chauhan*, S. Létoffé, F. Fischer, H. Reuse, C. Beloin and J. M. Ghigo (2014), “pH-mediated potentiation of aminoglycosides kills bacterial persisters and eradicates in vivo biofilms”, The Journal of Infectious disease”, (1); 210(9):1357-66, Impact Factor 6.344, *equal contribution
  • Ashwini Chauhan, Bernardin, A.; Mussard, W.; Kriegel, I.; Esteve, M. Ghigo, J.M.; Beloin, C. and V. Semetey (2014), “In vivo inhibition of bacterial biofilm development on totally implantable venous catheters by biomimetic glycocalyx-like polymers”, The Journal of Infectious diseases, 1;210(9):1347-56 Impact Factor 6.344, *Editorial commentary and cover page.
  • Lebeaux, D. Fernández-Hidalgo, N. Chauhan, Ashwini, Lee, S. Ghigo, J.M. Almirante, B. and C.Beloin (2013), “Management of totally implantable venous access port-related infections”, challenges and perspectives, Lancet, 14(2), 146-59 , Impact Factor 19.45, (REVIEW)

2013

  • Chauhan, Ashwini ; Sakamoto, S. Ghigo J.M. and C. Beloin (2013), “Did I pick the right colony?”, Phase variation pitfalls in the study of regulation of phase variable antigen, 43 adhesin PloS One, 8(9), Impact Factor 3.53
  • D. Lebeaux*, Chauhan, Ashwini*, O. Rendueles and C. Beloin (2013) , “From in vitro to in vivo Models of Bacterial Biofilm-Related Infections”, Pathogens, 2(2), 288-356 (REVIEW) * equal contribution

2012

  • Chauhan, Ashwini ; D. Lebeaux, J.M. Ghigo, C. Beloin (2012), “Full and broad-spectrum eradication of catheter-associated biofilms using gentamicin-EDTA antibiotic lock therapy”, Antimicrob Agents Chemotherapy, 56 (12), 6310-8, Impact Factor 4.45 * recommended by Faculty of 1000.
  • Chauhan, Ashwini ; D. Lebeaux, B. Decante, I. Kriegel, M. Escande, J.M. Ghigo and C. Beloin (2012), “A rat model of central venous catheter to study establishment of long-term bacterial biofilm and related acute and chronic infections”, PloS One, 7(5), e37281, Impact Factor 3.53

Research Publication Details (Before 2011):

2009
M. Kiran*, Chauhan, Ashwini*,  E. Maloney, R. Dziedzic, S. K. Mukherjee, M. Madiraju and M. Rajagopalan (2009),Mycobacterium tuberculosis ftsH expression in response to stress and viability”, Tuberculosis, 89(suppl1) S70-73,Impact Factor 3.5, *equal contribution

• M. Kiran, E. Maloney, H. Lofton, Ashwini Chauhan, R. Jensen, R. Dziedzic, M. V.V.S. Madiraju and M. Rajagopalan (2009), “Mycobacterium tuberculosis FtsZ expression and minimal promoter activity”, Tuberculosis, 89(suppl1) S60-64, Impact Factor 3.5

2006

• Chauhan, Ashwini, H. Lofton, E. Maloney, J. Moore, M. Fol, M. V.V. S. Madiraju and M. Rajagopalan (2006), “Interference of Mycobacterium tuberculosis cell division by Rv2719c, a cell wall hydrolase”, Molecular Microbiology, 62(1); 132-147, Impact Factor 5.03

• M. Fol, Ashwini Chauhan, N. K. Nair, E. Maloney, M. Moomey, C. jagannath, M. V. V. S. Madiraju and M. Rajagopalan (2006), “Modulation of Mycobacterium tuberculosis proliferation by MtrA, an essential two-component response regulator”, Molecular Microbiology, 60(3); 643-657. Impact Factor 5.03

Chauhan, Ashwini ; M. V V S Madiraju, M. Fol, H. Lofton, E. Maloney, R. Reynolds, M. Rajagopalan (2006), “Mycobacterium tuberculosis cells growing in macrophages are filamentous and deficient in FtsZ rings”, Journal of Bacteriology”, 188:1856-65, Impact Factor 2.69

2005
M. Rajagopalan, E. Maloney, J. Dziadek, M. Poplawska, H. Lofton, Ashwini Chauhan, M. V V S Madiraju (2005), “Genetic evidence that mycobacterial FtsZ and FtsW proteins interact, and co localize to the division site in Mycobacterium smegmatis”, FEMS Microbiol Lett, 250:9-17 Impact Factor 2.72

M. Rajagopalan, M. A L Atkinson, H. Lofton, Ashwini Chauhan, M. V Madiraju (2005), “Mutations in the GTP-binding and synergy loop domains of Mycobacterium tuberculosis ftsZ compromise its function in vitro and in vivo”, Biochem Biophys Res Commun, 331:1171 Impact Factor 2.28

2003
• V. C. Kalia, Ashwini Chauhan, G. Bhattacharyya & R. Genomic (2003), “databases yield novel bioplastic producers”, Nature Biotechnology, 21, 845 - 846. Impact Factor 41.514

  • Kalia, V. C.; Lal, S.; Ghai, R.; Mandal, M.; Chauhan, Ashwini (2003),Mining genomic databases to identify novel hydrogen producersTrends in Biotechnology”, Vol. 21 (4),Impact Factor 11.958 (REVIEW)

 

2002

  • Chauhan, Ashwini ;S . Bhatia and D.K. Maheshwari (2002), “A preliminary study on decolarization of triphenyl methane dyes by Coriolus hirsutus”, Journal of Indian Botanical Society, 295-297.